Publications

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Ralston A. Investigations at the 'Four-Front' of Mammalian Development. Trends Genet.. 2016 Apr 32;(8):457-8. PubMed PMID: 27256906 

Parenti A, Halbisen MA, Wang K, Latham K, Ralston A. OSKM Induce Extraembryonic Endoderm Stem Cells in Parallel to Induced Pluripotent Stem Cells. Stem Cell Reports. 2016 Apr 12;6(4):447-55. PubMed PMID: 26947975 

Parenti A, Ralston A. Three, Two, One... TROPHO-BLAST OFF! Cell Stem Cell. 2015 Nov 5;17(5):499-500. PubMed PMID: 26544108

Frum T, Ralston A. Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst. Trends Genet. 2015 Jul 31;(7):402-410. PubMed PMID: 25999217

Blij S, Parenti A, Tabatabai-Yazdi N, Ralston A. Cdx2 Efficiently Induces Trophoblast Stem-Like Cells in Naïve, but Not Primed, Pluripotent Stem Cells. Stem Cells Dev. 2015 Jun 1;24(11):1352-65. PubMed PMID: 25625326

Wicklow E, Blij S, Frum T, Hirate Y, Sasaki H, Lang RA, Ralston A. HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genetics 2014 Oct 23;10(10). PubMed PMID: 25340657

Halbisen MA, Ralston A. Have you seen? Shaking up the salt and pepper: origins of cellular heterogeneity in the inner cell mass of the blastocyst. EMBO J. 2014 Feb 18;33(4):280-81. PubMed PMID: 24469250

Frum T, Halbisen MA, Wang C, Amiri H, Robson P, Ralston A. Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst. Dev Cell. 2013 Jun 24;25(6):610-22. PubMed PMID: 23747191

Blij S, Frum T, Akyol A, Fearon E, Ralston A. Maternal Cdx2 is dispensable for mouse development. Development. 2012 Nov;139(21):3969-72. PubMed PMID: 22992952

Yamanaka Y, Ralston A. Early embryonic cell fate decisions in the mouse. Adv Exp Med Biol. 2010;695:1-13. PubMed PMID:21222195

Yamanaka Y, Ralston A. (2010) Establishment of early lineages in the mouse embryo. In K. Plath and Meshorer (Eds.) The Cell Biology of Stem Cells (pp 1-13). Landes Biosciences, Austin, TX. Download this chapter.pdf

Rugg-Gunn PJ, Cox BJ, Ralston A, Rossant J. Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10783-90. PubMed PMID: 20479220

Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, Rossant J. Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development. 2010 Feb;137(3):395-403. PubMed PMID: 20081188

Ralston A, Rossant J. The genetics of induced pluripotency. Reproduction. 2010 Jan;139(1):35-44. PubMed PMID: 19605512

Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H, Sasaki H. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell. 2009 Mar;16(3):398-410. PubMed PMID: 19289085

Serpe M, Umulis D, Ralston A, Chen J, Olson DJ, Avanesov A, Othmer H, O'Connor MB, Blair SS. The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. Dev Cell. 2008 Jun;14(6):940-53. PubMed PMID: 18539121

Ralston A, Rossant J. Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev Biol. 2008 Jan 15;313(2):614-29. PubMed PMID: 18067887

Yamanaka Y, Ralston A, Stephenson RO, Rossant J. Cell and molecular regulation of the mouse blastocyst. Dev Dyn. 2006 Sep;235(9):2301-14. PubMed PMID: 16773657

Ralston A, Rossant J. How signaling promotes stem cell survival: trophoblast stem cells and Shp2. Dev Cell. 2006 Mar;10(3):275-6. PubMed PMID: 16516829

Ralston A, Rossant J. Genetic regulation of stem cell origins in the mouse embryo. Clin Genet. 2005 Aug;68(2):106-12. PubMed PMID: 15996204

Shimmi O, Ralston A, Blair SS, O'Connor MB. The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. Dev Biol. 2005 Jun 1;282(1):70-83. PubMed PMID: 15936330

Serpe M, Ralston A, Blair SS, O'Connor MB. Matching catalytic activity to developmental function: tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing. Development. 2005 Jun;132(11):2645-56. PubMed PMID: 15872004

Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, Rossant J. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 2005 May;132(9):2093-102. PubMed PMID: 15788452

Ralston A, Blair SS. Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Dev Biol. 2005 Apr 1;280(1):187-200. PubMed PMID: 15766758

Conley CA, Silburn R, Singer MA, Ralston A, Rohwer-Nutter D, Olson DJ, Gelbart W, Blair SS. Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila. Development. 2000 Sep;127(18):3947-59. PubMed PMID: 10952893

Blair SS, Ralston A. Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. Development. 1997 Oct;124(20):4053-63. PubMed PMID: 9374402


~ Header image of preimplatation mouse blastocyst courtesy of T. Frum. ~ Last updated 2015 with Mura CMS by M. Halbisen.